SIL is worried, very worried, which doesn't keep his reptilian skin in the best condition. Confined in a cold detention cell on the moon, awaiting a deportation hearing for trial on drugs offenses on Earth, he faces a death sentence if the application is successful and he is found guilty. And his employers at the Universal Monetary Fund aren't pleased either. Not at all. As time runs out and friends desert him, SIL must use all of his devious, vile, underhanded, ruthless, and amoral business acumen to survive. Can he possibly slime his way out of this one.

As melhores amigas Edina (Jennifer Saunders) e Patsy (Joanna Lumley) estão curtindo a vida que levam, cheias de dinheiro, glamour e amores. Entretanto, após um incidente, elas se veem no meio de uma tempestade de críticas na mídia e terão de se acostumar ao desprezo da sociedade.